Guys,
I was wondering if anyone could point towards specific literature on the differences between the commonly used IV narcotics (morphine, hydromorphone, fentanyl) and the clinical implications of those differences. Uptodate is rather poor in this regard and the surgery textbooks even worse. In my understanding, the main differences are the PK/PD and the histamine effects of morphine (vasodilation etc).
Do you know of any relevant clinical evidence? Where do you base your decisions on postop...
Postoperative pain management
I was wondering if anyone could point towards specific literature on the differences between the commonly used IV narcotics (morphine, hydromorphone, fentanyl) and the clinical implications of those differences. Uptodate is rather poor in this regard and the surgery textbooks even worse. In my understanding, the main differences are the PK/PD and the histamine effects of morphine (vasodilation etc).
Do you know of any relevant clinical evidence? Where do you base your decisions on postop...
Postoperative pain management